Abstract
Recently, the use of nanotechnology has been expanding very rapidly in diverse areas of research, such as consumer products, energy, materials, and medicine. This is especially true in nanomedicine, due to physicochemical properties, such as mechanical, chemical, magnetic, optical, and electrical properties, compared with bulk materials. The first goal of this study was to produce Zinc oxide nanoparticles (ZnONPs) using two different biological resources as reducing agents, Calocybe indica fruiting bodies. The second goal was to investigate the antimicrobial potential of the as-prepared ZnONPs in lung cancer cells. The final goal was to investigate the role of p53 in the cellular response elicited by ZnONPs. The synthesis and characterization of ZnONPs were assessed by various analytical techniques, including ultraviolet-visible (UV-vis) spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and transmission electron microscopy (TEM). The present findings could provide insight into the future development of green synthesis in ZnO nanoparticles, along with their antimicrobial activity.
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