Biosensor development for C-reactive protein detection: A review

Abstract

BackgroundC-reactive protein (CRP) is an acute-phase protein. It's level is increased during several disorders. There are various conventional methods available for the detection of CRP such as immunoagglutination, immunoturbidimetry, and enzyme-linked immunosorbent assay (ELISA) kits but these techniques limit the analysis of CRP due to time consumption, expensive, sophisticated equipment, and the requirement for trained professionals. Recently, to overcome these impediments biosensor development has gathered much interest. Distinct biosensors based on the principles of electrochemistry, optics, colorimetry, and piezoelectricity have been already developed which has played a key role for CRP detection in the body fluid. RationaleThe study was conducted to summarize the knowledge of available literature on biosensors developed for CRP detection. ScopeThe article gives an overview of the published data related to biosensor development for CRP detection in a single article. It is required because different research groups are working in the detection and biosensors development field. This article can provide an overview of the recent literature published related to the topic. DemandC-reactive protein is a common and early-rising biomarker for several inflammations. The development of biosensors has provided various benefits over the traditional available methods therefore, it is required that different principles must be studied to know several advantages and disadvantages of the material used before further research. In this review article the data from different platforms is summarized on a single platform this would be more helpful to the readers. AdvantagesThe literature review describes about the different types of biosensors developed for the detection of CRP, their working principle, detection range, limit of detection, response time, and volume of required sample, also advantages and disadvantages of the methods included for the biosensor preparation. The article will help to study the comparison of different methods or techniques available for CRP identification. This can increase the interest and knowledge of the readers.