Abstract
Localized surface plasmon resonance (LSPR)-based biosensors have recently garnered increasing attention due to their potential to allow label-free, portable, low-cost, and real-time monitoring of diverse analytes. Recent developments in this technology have focused on biochemical markers in clinical and environmental settings coupled with advances in nanostructure technology. Therefore, this review focuses on the recent advances in LSPR-based biosensor technology for the detection of diverse chemicals and biomolecules. Moreover, we also provide recent examples of sensing strategies based on diverse nanostructure platforms, in addition to their advantages and limitations. Finally, this review discusses potential strategies for the development of biosensors with enhanced sensing performance.
Highlights
Biosensors are analytical devices that consist of biological recognition elements, transducer components, and electronic systems
Point-of-care (POC) testing and monitoring has become an ongoing trend for the development of medical and environmental applications due to the increasing need for user-centered systems, and more convenient, inexpensive, portable, and accurate detection systems that can be deployed in a wide variety of scenarios [1]
The rapid, accurate, and multiplexed identification of biomarkers or causative agents in a variety of settings in a low-cost manner remains a major challenge of this field
Summary
Biosensors are analytical devices that consist of biological recognition elements, transducer components, and electronic systems. A recent report by the World Health Organization (WHO) suggested that the ideal analytical method should be affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and deliverable to end-users These criteria, represented by the acronym ASSURED, provide a framework for the evaluation of detection devices, especially in resource-limited regions or field applications. Focus is given to the biomoleculedetecting strategies and technologies based in diverse nanostructure platforms, which can be divided into three different categories: solution phase-based colloidal nanoparticles, flat substrate-based platforms, and nanoparticle (NP)-coated optical fiber platforms An approach that may enable the development of biosensors with an enhanced sensing performance for POC detection is described to help achieve the long-term goal of its practical use
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