Biorisks Associated with Synthetic Biology: Pathogenic Plasmid Transfer to Probiotic or Starter Cultures

Abstract

Synthetic biology has revolutionized the field of biotechnology, enabling precise manipulation of biological systems for diverse applications. While the advancements in this rapidly evolving field are promising, there is a growing concern about potential biorisks associated with synthetic biology techniques. One significant risk is the transfer of pathogenic plasmids to probiotic or starter cultures, which could lead to unintended consequences and pose serious threats to human health. This paper reviews the biorisks of pathogenic plasmid transfer, discusses potential consequences, and proposes risk mitigation strategies to ensure responsible and safe use of synthetic biology in probiotics and starter cultures.