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Abstract
The glucuronidations of pentazocine (PA) and salicylamide (SAM) were investigated in the microsomes of rabbit liver and the small intestine. 1) PA glucuronidation was inhibited competitively by the addition of SAM. 2) The inhibitory effect on PA glucuronidation was found to be greater with the addition of o-, m- or p-nitrophenol, and lesser with the addition of SAM and o-aminophenol. Salicylic acid, p-aminosalicylic acid or gentisic acid showed only slight inhibitory effect, and acetaminophen showed no effect. 3) It appeared that the degree of inhibition of PA glucuronidation by the addition of one of the phenolic compounds was almost the same in the liver and small intestine.
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Schedule a callMore From: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
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