Abstract
The serum concentration of unchanged pentazocine (PA) was investigated in rabbits when PA was administered concurrently with acetaminophen, salicylamide (SAM), salicylic acid, acetylsalicylic acid, or p-aminosalicylic acid. The serum concentration of unchanged PA increased when 20 mg/kg PA was administered concurrently with 80 mg/kg SAM as compared with the administration of 20 mg/kg PA alone, but no similar results were obtained with the other drugs. The co-administration of PA and SAM also decreased serum and urinary PA glucuronide. On the other hand, when 80 mg/kg SAM and 375.6 mg/kg PA were administered together, the serum and urinary concentration of unchanged SAM was increased, while SAM glucuronide was decreased. We posit that the effect noted in the simultaneous 20 mg/kg PA and 80 mg/kg SAM administration experiments is due to competitive inhibition of glucuronidation.
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