Biomolecular Sensors Based on Microfluidics-Embedded Graphene Field-Effect Transistors

Abstract

With the rapid pace of discovery of molecular biomarkers associated with cancer and other diseases, there is a need for bioanalytical techniques able to detect and quantify large panels of biomolecules, with high throughput and accuracy. Nanoelectronic sensors are emerging in this field due to their potential for improved sensitivity, parallelization and portability. In this presentation, I will introduce our recent progress in assembling nanoelectronic biomolecular sensors based on graphene field-effect transistor device arrays combined with microfluidic circuitry. In particular, I will present two designs targeting either DNA oligonucleotide sequences or antibody-antigen coupling, and I will describe their electrical signatures for specific and non-specific biomolecular interactions with the graphene material. Finally, I will discuss the electronic detection of breast cancer and leukemia biomarkers for clinical diagnostics applications.