Biomimetic Synthesis of Carbonate Hydroxyapatite in the Presence of Chondroitin Sulfate

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Carbonate hydroxyapatite (CHA) was prepared from the prototype of synovia in the presence of chondroitin sulfate (CS). The presence of the polysaccharide in the model solution had no effect on the solid phase composition of the resulting sample, but favored a decrease in the specific surface area. An adsorption experiment was carried out to elucidate the laws of interaction between CS and the CHA surface, and the Langmuir model was shown to fit CS adsorption on CHA. The dissolution of prepared samples in acetate buffer solution (pH 5.5) and in 0.9% NaCl was a two-stage process. Samples containing chondroitin sulfate had lower dissolution rates compared to those of the additive-free solid phase.