Abstract
A novel molecularly imprinted polymer (MIP)-modified quartz crystal microbalance (QCM) sensor with high selectivity has been developed for the determination of folic acid via activator generated-atom transfer radical polymerization (AGET-ATRP) technique. It requires an alkyl halide (R-X) as an initiator, a transition metal complex as a catalyst, and an amine as reducing agent. Herein, chlorosilane was used as initiator which was grafted onto the self assembled monolayer modified-quartz crystal surface followed by the addition of pre-polymer mixture which latter underwent thermal cross-linking resulting in MIP-modified QCM sensor. The linear working range (quantification) was found to be 0.6-26.0 μg L-1, with the detection limit as low as 0.08 μg L-1 (S/N=3).
Highlights
Quartz crystal microbalance (QCM) is a simple, low-cost, high-resolution mass sensing technique [1], there is no specific selectivity
We investigate a possible route to prepare ultra-thin molecularly imprinted polymer (MIP) [poly
The peak due to MIP 6.8 ppm shifted to 7.5 ppm, and the peaks due to template (-COOH, 9.5; -OH 10.8 and 5.2 ppm) were shifted to 10.0, 11.2, and 5.8 ppm, respectively after folic acid (FA) rebinding with MIP
Summary
Quartz crystal microbalance (QCM) is a simple, low-cost, high-resolution mass sensing technique [1], there is no specific selectivity. Pre-coated (QCM)-based piezoelectric immuno-sensors have received widespread applications in the analysis of clinical targets [2], the monitoring of environmental contaminants, such as pathogen and bacteria [3] and the detection of biomolecular interaction [4] This ensured attractive performance, such as high specificity, low cost, ease of use, and rapidness of detection. The most attractive one is molecular imprinted polymers (MIPs) to obtain a selective polymer layer on the surface of QCM [5]. (The. QCM sensor coated with non-imprinted polymer [NIP, poly dimethacrylate)], having same polymer motif as that of MIP, was prepared in the similar manner but, without template)
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