Abstract
Molecularly imprinted polymers (MIPs) as artificial antibodies have received considerable scientific attention in the past years in the field of (bio)sensors since they have unique features that distinguish them from natural antibodies such as robustness, multiple binding sites, low cost, facile preparation and high stability under extreme operation conditions (higher pH and temperature values, etc.). On the other hand, the Quartz Crystal Microbalance (QCM) is an analytical tool based on the measurement of small mass changes on the sensor surface. QCM sensors are practical and convenient monitoring tools because of their specificity, sensitivity, high accuracy, stability and reproducibility. QCM devices are highly suitable for converting the recognition process achieved using MIP-based memories into a sensor signal. Therefore, the combination of a QCM and MIPs as synthetic receptors enhances the sensitivity through MIP process-based multiplexed binding sites using size, 3D-shape and chemical function having molecular memories of the prepared sensor system toward the target compound to be detected. This review aims to highlight and summarize the recent progress and studies in the field of (bio)sensor systems based on QCMs combined with molecular imprinting technology.
Highlights
Biomolecular recognition plays a crucial role in biological systems where the enzyme-substrate, DNA-protein and antibody-antigen interactions are carried out [1]
In a study reported by Lee et al [37] Molecularly imprinted polymers (MIPs) film-coated Quartz Crystal Microbalance (QCM) sensors were used for the selective recognition of lipase, amylase and lysozyme which are digestive enzymes found in saliva
Sensor systems based on the molecular imprinting technique have been used in various application areas showed that these sensor systems are promising for selective recognition
Summary
Biomolecular recognition plays a crucial role in biological systems where the enzyme-substrate, DNA-protein and antibody-antigen interactions are carried out [1] These interactions and binding phenomena are usually based on lock and key models where receptors and substrates interact with each other. Addition, MIP layers beofformed bylayer electropolymerization on thebysurface of QCM sensor In [13]. Some special should be applied to increase the adhesion of MIP layers on the surface of the sensor system. There are many reported studies on the applications of QCM sensors based on molecular imprinting. In one of the first reported studies performed by Dickert and Hayden [15], a MIP-based QCM sensor for selective recognition of yeast cells was prepared prepared by by surface surface imprinting imprinting (Figure (Figure 2).
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