Abstract
Rampant use of antibiotics and emergence of zoonotic diseases lead to serious health hazards worldwide. Amidst the foremost category of microbial infections, fungal infections are deleterious and challenging due to their eukaryotic cellular feature. The genus Aspergillosis is one of the major causes of global mortality associated with chronic fungal infections ensuing the developement of novel antifungal agents. Inspired by antimicrobial peptides (AMPs), different amino acid-based pH responsive cationic biocompatible polymers have been designed to investigate the fungicidal activities against Aspergillus niger (A. niger). The structure-activity relationships and mechanism of action have been studied thoroughly demonstrating the effective inhibition of hyphal growth and distortion of conidiophores in A. niger. Detailed morphological analysis provide mechanistic insight explicating that the aqueous solution properties of the side chain groups of individual amino acids significantly influence the fungicidal activities.
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