New edge of antibiotic development: antimicrobial peptides and corresponding resistance.

Nadia S Parachin,Octavio L Franco

doi:10.3389/fmicb.2014.00147

Abstract

New edge of antibiotic development: antimicrobial peptides and corresponding resistance.

Highlights

In the last years severe efforts turned into extensive research on development of novel antimicrobial compounds
For example defensins commonly found in plants, fungi, insect and mammalian cells are small cationic peptides of 45–54 amino acid residues with a conserved signature of cysteines, which can form three to four disulfide bridges
Defensins isolated from plants have been considered as a biotechnological tool to improve crop production as recently reviewed (Lacerda et al, 2014). Among their advantages low effective fungicide concentrations and decreased environmental impact have been focused when compared to most common chemicals utilized for fungi control

Summary

Introduction

In the last years severe efforts turned into extensive research on development of novel antimicrobial compounds. Defensins isolated from plants have been considered as a biotechnological tool to improve crop production as recently reviewed (Lacerda et al, 2014). Many studies have focused in construction of genetic modified plants that over produce such molecules in order to reduce crop losses by fungi infection.

Results

Conclusion