Abstract
Diabetes mellitus (DM) has been treated with herbs for centuries and many herbs reported to exert antidiabetic activity. Laurus nobilis is an aromatic herb belonging to the Lauraceae family, commonly known as bay. This study aimed to investigate the activity of Laurus nobilis leave extracts on histopathological and biochemical changes in β-cells of streptozotocin (STZ)-induced diabetic rats. Thirty healthy adult male albino rats were included in the study and divided equally into 5 groups for 4 weeks as follow; control group (C), diabetic group (D), diabetic Laurus nobilis extract group (DLN), Laurus nobilis extract group (LN) and diabetic acarbose (DA) group. Histopathologically, D group rats exhibited various degenerative and necrotic changes in their liver, pancreas and kidney, whereas the DLN rats had nearly normal histology. Insulin immunostaining in the pancreatic beta cells was decreased in the D group compared to the C group, whereas the DLN group was similar to the C group. The glucose concentration decreased significantly in both diabetic rats treated with L. nobilis and acarbose (p < 0.05). Additionally, the levels of aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT) enzyme were significantly decreased in both diabetic rats treated with L. nobilis and acarbose, compared to the D group (p ˃ 0.05). Outcomes of this study said that leave extracts of L. nobilis has valuable effect on blood glucose level and ameliorative effect on regeneration of pancreatic islets, it also restored the altered liver enzymes, urea, creatine kinase, total protein levels, calcium and ferritin to near normal.
Highlights
Diabetes mellitus (DM) is a chronic endocrine disorder of multiple etiologies distinguished by hyperglycemia resulting from defects in in sulin secretion, insulin action, or both [1]
This study aimed to evaluate the ef fects of Laurus nobilis leave extracts on biochemical and histopatholog ical changes of pancreas, liver and kidney on diabetic rats
Diabetes model with streptozotocin (STZ) Diabetes mellitus was induced by single intraperitoneal (IP) injection of freshly prepared STZ (Sigma-aldrich, Saint Louis, MO) at dose of 70 mg kg − 1 b.w. dissolved in 0.01 M citrate buffer, pH 4.5 [30]
Summary
Diabetes mellitus (DM) is a chronic endocrine disorder of multiple etiologies distinguished by hyperglycemia resulting from defects in in sulin secretion, insulin action, or both [1]. The clinical diagnosis of diabetes is often indicated by the presence of symptoms such as polyuria, polydipsia, unexplained weight loss, and is confirmed by documented hyperglycemia [2,3]. Natural supplements are widely used around the world to treat diabetes, but medical research does not support their effectiveness. Traditional plants have been used as a cure for diabetes for a long time before the introduction of modern medicine. Traditional herbal treat ments have been shown to possess successful pharmacological activity, such as in the case with metformin, isolated from Galega officinalis [10,11,12]
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