Biomechanical properties of animals bones and the influence of oncologic drug on pig femur

Abstract

Over the years, we have seen how, thanks to experimentation on animal models, the foundations have been laid in the field of implantology. In most cases, studies related to the bone scale are carried out on the species that are most similar in their movements and behavior to humans. The femur has been selected as the reference bone for our test, selecting as animals to experiment with the goat breed, the bovine breed and the porcine breed for their similarity to the human body, obtaining specimens of the cortical part of the bone. Destructive bending tests will be carried out in the same way on each of the femur fragments of each animal. When interpreting the results, we will be guided by taking sections of the transverse and longitudinal part of the bone, performing the tests in both cases inside the femur, and once the results have been obtained, we will proceed to their subsequent evaluation. We relate the bone resistance of the samples to the effect of an oncological drug, Altan Zolendronic Acid 4 mg/ 100 ml solution for perfusion EFG, administered in cases of bone metastasis.