Abstract
Osteoarthritis is widely believed to result from local mechanical factors acting within the context of systemic susceptibility. The underlying pathological changes of osteoarthritis appear to be the result of a complex interplay between mechanical, cellular, and biochemical forces. Of these factors, mechanical forces are paramount. This talk will review the current understanding of the etiopathogenesis of osteoarthritis and more specifically examine the critical role of biomechanics in disease pathogenesis. There are a number of ways the mechanical forces across the joint can be measured including a large number that rely heavily upon imaging methods. Extensive investigation of femorotibial alignment has demonstrated its pivotal role in knee OA progression. Greater attention to the important role of mechanical factors in OA etiopathogenesis is required if we are to find ways of reducing the public health impact of this condition. Therapies directed at unloading or reducing the forces in the knee are not used as frequently as they should, there is substantial opportunity for further therapeutic development in this area.
Published Version
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