Biomarkers related to the intrathecal humoral immune response as laboratory tools for multiple sclerosis diagnosis

Abstract

In cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients, the intrathecal synthesis (IS) of affinity-maturated IgG class antibodies secreted by transmigrated B cells, is considered as a hallmark of the disease. It is classically revealed by CSF isofocusing test (detection of IgG Oligoclonal bands (OCB) in CSF, considered as “the gold standard”), Total IgG Index and/or Reiber diagram. Our aim is to analyse the comparative performance of different CSF testing techniques for MS diagnosis.