Abstract
This study is intended to explore effective and sensitive biomarkers for kidney damage after low level arsenic (As) exposure and to provide scientific evidence on cut-off values of arsenic concentrations in drinking water. The levels of α1-MG detected in urine samples were found to have statistically significant differences between high As group (As>0.05mg/L) and a combination of low and medium As exposure groups (As<0.05mg/L, p=0.018), as well as between the patient and high As groups (As in two group were both higher than 0.05mg/L, p<0.001). After the logistic regression analysis the AUC values of α1-MG between two comparisons were 0.613 and 0.701, and p value was less than 0.05. The present data demonstrate the potential value of α1-MG excretion as a biomarker of renal toxicity, which could contribute to the enforcement of the maximum limit of 0.05mg/L arsenic in drinking water for non-central water supply in rural areas.
Published Version
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