Abstract
Despite its limited utility, the serum creatinine remains an essential part of both the RIFLE and AKIN criteria for the diagnosis of acute kidney injury (AKI) [1]. Due to the delayed rise in creatinine following injury, nephrologists and intensivists alike continue to search for the holy grail of AKI: an early and reliable biomarker of kidney injury. Biomarkers are biological parameters that may indicate normal or pathological processes or responses to interventions and may be objectively quantified. The sensitivity, specificity and time course of a biomarker are critical factors in determining its use in any disease process. But more importantly, the utility of a biomarker depends on the purpose it is expected to fulfill. Summarzing current literature, it appears that an ideal biomarker for AKI should fulfill the following criteria:
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