Abstract
BackgroundThere is a growing body of evidence regarding the association between Adiponectin and mental disorders. We aim to evaluate the association between serum level of Adiponectin hormone and postpartum depression and marital satisfaction scores.MethodsA prospective cohort study of 90 pregnant women was conducted in Mahdieh Hospital, Tehran, Iran. Blood samples were collected during the first 24 h after delivery. The serum Adiponectin concentration was measured with an Enzyme-Linked Immunosorbent Assay (ELISA) kit. The depression score was measured using a validated Iranian version of the Edinburgh Postnatal Depression Scale (EPDS) questionnaire at six weeks (6-weeks) and twelve weeks (12-weeks) after delivery. Using the Kansas questionnaire at twelve weeks (12-weeks) after delivery, the marital satisfaction score was measured. The measurements were compared between two groups, satisfied and dissatisfied mothers. P-values lower than 0.05 were considered significant.ResultsThe mean serum level of Adiponectin was significantly higher in the dissatisfied group. It was 10.9 ± 13.4 μg/ml and 15.2 ± 17.7 μg /ml in the satisfied and dissatisfied groups, respectively (P = 0.04).The postpartum depression scores of 6- and 12-weeks after delivery were significantly higher in the dissatisfied group. At 6-weeks after delivery, the postpartum depression scores were 3.6 ± 3 and 8.7 ± 5.6 in satisfied and dissatisfied groups, respectively. Those were 2.7 ± 2.7 and 7.6 ± 5 at 12-weeks after delivery, respectively. There was a significant difference statistically (P < 0.001).ConclusionMothers in the dissatisfied group, experienced higher depression scores at 12-weeks postpartum while they had shown higher serum Adiponectin levels at the first 24 h after delivery.
Highlights
There is a growing body of evidence regarding the association between Adiponectin and mental disorders
This study considered the mode of delivery along with the Body Mass Index (BMI) into different groups as confounder factors when analyzing depression symptoms
There was no difference in the baseline characteristics of groups including age, gravidity, parity, number of previous abortions, number of living children, gestational age, BMI, employment, education, and type of delivery (Table 1)
Summary
There is a growing body of evidence regarding the association between Adiponectin and mental disorders. We aim to evaluate the association between serum level of Adiponectin hormone and postpartum depression and marital satisfaction scores. Some mothers encounter with signs and manifestations of depression during the first week after delivery that are called Postpartum Depression (PPD) [3]. Recent studies discovered the role of the proliferation of hippocampal cells on the prevention of depression. This type of neurogenesis can be stimulated by hormones, such as Adiponectin [2]. Adiponectin is a 244 amino acid protein that is associated with multiple metabolic processes in the body [6–8]. Adiponectin’s level reaches its maximum before mid-pregnancy and decreases and continues to fall till 5 to 8 weeks postpartum [9]
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