Abstract
Background: The authors of the current review aspire to inspire researchers by using the SAR technique to discover a promising and novel therapeutic agent. Currently, we don’t have a drug that is both active and non-toxic for the treatment of severe diseases like cancer, diabetes, hypertension, and neurodegenerative diseases. In a summary, thiazolidinedione (TZD) heterocyclic ligands have a spectacular standing in medicinal chemistry's synthetic and pharmacological approaches. Thiazolidinedione (TZD) core upon the replacement of different substitutes, gives a wide range of organic action by the utilization of various components on various objective destinations.
 Methods: We looked through the logical data set utilizing relevant keywords. Among the looked through writing, certain research papers were gathered which resolved our inquiries. The vital discoveries of the key findings of these studies were incorporated alongside their significance. 
 Results: There has been an explosion in the introduction of new classes of pharmacological agents having Thiazolidinedione moieties. Subsequently, new medications with Thiazolidinedione moieties came up with improved compliance and reduced side effects.
 Conclusion: The present review describes the significance of the Thiazolidinedione nucleus and its derivatives as a therapeutic agent with an emphasis on the past as well as recent developments.
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