Abstract
Pyridopyridazine compounds are important nitrogen atom containing heterocyclic compounds due to their pharmacological versatility. This heterocycle system characterized a structural feature for different types of bioactive compounds that exhibiting various types of biological activities which make it an attractive scaffold for the design and development of new drug molecules. This article provided information about the pharmacological properties of pyridopyridazines derivatives.
Highlights
Heterocyclic compounds are playing key role in the drug discovery and design because of their different types of biological properties
Among the nitrogen containing six-member heterocylic compounds, the pyridine or piperidine structural is often found in naturally occurring bioactive compounds such as alkaloids[2]
This review summarizes the current information about the pharmacological activites of pyridopyridazine derivatives
Summary
Heterocyclic compounds are playing key role in the drug discovery and design because of their different types of biological properties. Pyridazine is the important class of compounds due to their diverse pharmacological activities This privileged structure attracts the interest of medicinal chemists as a nucleus of potential therapeutic utility[9,10,11]. Pyridazinones is an important class of compounds mainly due to their diverse biological activities like analgesic, anti-inflammatory, antibacterial, herbicidal, antifungal, antituberculotic, anti-AIDs, antitumour, antihypertensive, anticonvulsant, anticancer, and antiviral activities[16,17,18,19,20]. The introduction of a nitrogen atom into the benzo ring of phthalazines leads to pyridopyridazines This scaffold can be functionalized at different ring positions, which makes it attractive compound for designing and development of the new pyridopyridazine drugs[21,22]. Pyridopyridazine nucleus showed antiasthmatic[31], antidiabetic[32], antituberculosis[33] and antimicrobial activities[34]
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