Biological evaluation of nutritional traditional fruit Mangifera camptosperma against diabetes and hyperlipidemia

Abstract

IntroductionThe objective of the study was to determine antidiabetic and antihyperlipidemic effects of Mangifera camptosperma leaves extract using streptozotocin-induced animal model. MethodsThe leaves of M. camptosperma extracted with hydroethanolic (50:50) solvent using soxhlet apparatus. Traditional Chinese medicine (TCM) is often given as an adjuvant to alleviate diabetic symptoms. The plant extracts were used to determine presence of phytochemicals present in them using different tests. Diabetes was induced on animals using streptozotocin (STZ) 50 mg/kg through intra-peritoneal route. Oral administration of M. camptosperma extract at doses of 200 mg/kg and 400 mg/kg was used to assess its antidiabetic and antihyperlipidemic effects. ResultsThe phytochemical analysis showing presence of carbohydrates, alkaloids, tannins, glycosides, and flavonoids. The diabetic control group had blood glucose levels of 102 mg/kg and 126 mg/kg, respectively, after receiving the test medication, but the diabetic rats treated with the extract showed a substantial decrease to 90.11 ± 5.71 (200 mg/kg) and 82.12 ± 3.99 (400 mg/kg). If compared to the diabetic control group, the administration of 400 mg/kg of M. camptosperma for 21 days resulted in a substantial decrease (p < 0.05) in serum total cholesterol (106.12 ± 5.94 mg/dL) and triglyceride (83.11 ± 4.04 mg/dL), as well as an increase in HDL cholesterol (36.15 ± 3.04 mg/dL). This study found that while administered to diabetic rats, M. camptosperma lowered blood glucose levels and improved lipid profiles. DiscussionIt can be concluded from the study that the plant extract may be useful in treating hyperlipidemic and type-2 diabetes as an alternative medicine.