BIOLOGICAL COMPETITION BETWEEN STRUCTURALLY RELATED COMPOUNDS: CLINICAL IMPLICATIONS

Abstract

Editorial1 April 1949BIOLOGICAL COMPETITION BETWEEN STRUCTURALLY RELATED COMPOUNDS: CLINICAL IMPLICATIONSMILTON S. SACKSMILTON S. SACKSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-4-867 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe introduction in 1935 of the sulfonamide group of drugs1 opened a new era of chemotherapeutic endeavor. In 1940 the publication of the Woods-Fildes theory2 provided not only a satisfactory explanation of the mode of action of these drugs but also a highly important basis for a rational extension of chemotherapeutic research. The basis of the theory was the principle of the biological competition of structurally related compounds. The para-amino benzoic acid-sulfonamide relationship admirably exemplifies this concept.Woods reported that yeast extracts contained a substance which reversed the inhibitory action of sulfanilamide on the growth of hemolytic streptococci. This substance...1 DOMAGK G: Ein Beitrag zur Chemotherapie der bakteriellen Infectionen, Deutsch. med. Wchnschr., 1935, lxi, 250. CrossrefGoogle Scholar2 WOODS DD: The relation of p-amino benzoic acid to the mechanism of action of sulphanilamide, Brit. Jr. Exper. Path., 1940, xxi, 74. Google Scholar3 FILDES P: The mechanism of the anti-bacterial action of mercury, Brit. Jr. Exper. Path., 1940, xxi, 67. Google Scholar4 RUBBOGILLESPIE SDJM: Para-amino benzoic acid as a bacterial growth factor, Nature, 1940, cxlvi, 838. CrossrefGoogle Scholar5 ANGIERBOOTHHUTCHINGSMOWATSEMBSTOKSTADSUBBA ROWWALLERCOSULICHFAHRENBACHHULTQUISTKUHNORTHEYSEEGERSICKELSSMITH RBJHGLJHJELYCWDBMJMEEEHDRJPJM: The structure and synthesis of liver, L. casei factor, Science, 1946, ciii, 667. CrossrefGoogle Scholar6 LAMPENJONES JOMJ: Antagonism of sulfonamide inhibition of certain lactobacilli and enterococci by pteroyl-glutamic acid and related compounds, Jr. Biol. Chem., 1946, clxvi, 435. CrossrefGoogle Scholar7 LAMPENROEPKEJONES JORRMJ: The replacement of p-amino-benzoic acid in the growth of a mutant strain of E. coli , Jr. Biol. Chem., 1946, clxiv, 789. CrossrefGoogle Scholar8 WOOLEYWHITE DWAG: Production of thiamin deficiency disease by feeding of a pyridine analogue of thiamin, Jr. Biol. Chem., 1943, 285. CrossrefGoogle Scholar9 WOOLEYKRAMPITZ DWLO: Production of a scurvy-like condition by feeding of a compound structurally related to ascorbic acid, Jr. Exper. Med., 1943, lxxviii, 333. CrossrefGoogle Scholar10 OTT WH: Antipyridoxine activity of 2, 4-dimethyl-3-hydroxy-5-hydroxymethylpyridine in the chick, Proc. Soc. Exper. Biol. and Med., 1946, lxi, 125. CrossrefGoogle Scholar11 WOOLEY DW: Recent advances in the study of biological competition between structurally related compounds, Physiol. Rev., 1947, xxvii, 308. CrossrefGoogle Scholar12 WOOLEY DW: Biological antagonisms between structurally related compounds, Advances in Enzymology, 1946, vi, 129. Google Scholar13 WITTS LJ: Disturbances in coagulation of blood, Glasgow Med. Jr., 1942, cxxxvii, 57. Google Scholar14 KRANTZCARR JCCJ: The pharmacologic principles of medical practice, 1949, Baltimore, p. 679. Google Scholar15 FARBERDIAMONDMERCERSYLVESTERWOLFF SLKRDRFJA: Temporary remissions in acute leukemia in children produced by a folic acid antagonist, 4-amino pteroyl glutamic acid (aminopterin), New England Jr. Med., 1948, ccxxxviii, 787. CrossrefGoogle Scholar16 SACKSBRADFORD MSG: Unpublished observations. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAMINOPTERIN IN THE TREATMENT OF ACUTE LEUKEMIAP. W. C. 1 April 1949Volume 30, Issue 4Page: 867-870KeywordsDrugsSulfonamide Issue Published: 1 April 1949 PDF downloadLoading ...