AMINOPTERIN IN THE TREATMENT OF ACUTE LEUKEMIA

Abstract

Editorial1 December 1949AMINOPTERIN IN THE TREATMENT OF ACUTE LEUKEMIAP. W. C.P. W. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-31-6-1129 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe inhibition of the biological activity of an essential metabolite by compounds which are structurally related to it is now a well known phenomenon. The underlying principles believed to be involved and their importance in the study of fundamental metabolic processes have previously been discussed in this journal.1Folic acid (pteroyl glutamic acid) and its specific antagonists constitute one of the most carefully studied examples of this relationship. By an antagonist in this sense is meant a substance which will inhibit the growth ofLactobacillus caseiin a suitable culture medium containing barely adequate amounts of folic acid, but whose...1 SACKS MS: Biologic competition between structurally related compounds, Editorial, Ann. Int. Med., 1949, xxx, 867-870. LinkGoogle Scholar2 FARBER S: The action of pteroyl glutamic conjugates on man, Science, 1947, cvi, 619-621. CrossrefGoogle Scholar3 FARBER S: Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl glutamic acid (aminopterin), New England Med. Jr., 1948, ccxxxviii, 787-793. CrossrefGoogle Scholar4 FARBER S: Some observations on the effect of folic acid antagonists on acute leukemia and other forms of incurable cancer, Blood, 1949, iv, 160-167. CrossrefGoogle Scholar5 DAMESHEK W: The use of folic acid antagonists in the treatment of acute and subacute leukemia, Blood, 1949, iv, 168-171. CrossrefGoogle Scholar6 WOLMAN IJ: Leukemia in childhood. Preliminary report of response to aminopterin, Pennsylvania Med. Jr., 1949, lii, 474-481. Google Scholar7 STICKNEY JM: The treatment of acute leukemia with folic acid antagonists, Proc. Staff Meet., Mayo Clin., 1949, xxiv, 525-533. Google Scholar8 CONLEY CL: Aminopterin in the treatment of acute leukemia (abstract), Bull. Johns Hopkins Hosp., 1949, lxxxiv, 395. Google Scholar9 Personal communication. Google Scholar10 MEYER LM: Aminopterin (a folic acid antagonist) in the treatment of leukemia, Am. Jr. Clin. Path., 1949, xix, 119-126. CrossrefGoogle Scholar11 BERMAN L: Use of a folic acid antagonist in chronic leukemia, Am. Jr. Clin. Path., 1949, xix, 127-133. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1949Volume 31, Issue 6Page: 1129-1132KeywordsFolic acidLactobacillusMetabolic processesMetabolites Issue Published: 1 December 1949 PDF downloadLoading ...