Abstract
Publisher Summary This chapter describes trypanosomiasis research, focusing on its experimental and immunological aspects. The methods for the control of trypanosomiasis in man and animals can be considered under four different headings—control of host, control of vector, chemotherapy, and immunization. No anti-trypanosomal chemotherapeutic agents of radically new efficacy have been developed since 1965. Most work on the antigenic variation of trypanosomes has been on Trypanosoma (Trypanozoon) brucei. However, similar variation has been shown to occur in T. (Nannomonas) congolense. Changes in the immunoglobulin levels in hosts infected with a variety of trypanosome species have been the subject of several research studies. Most of the attention has been devoted to immunoglobulin M (IgM) because of the very marked changes taking place both in the plasma and in the cerebrospinal fluid in trypanosome infections, and which have useful diagnostic applications. The phenomenon of heterophile antibody production in trypanosomiasis is of obvious interest for diagnostic purposes.
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