Biological and pharmacological properties of thiamine monophosphate disulfide.

Abstract

Thiamine monophosphate disulfide (TMPDS) exhibited the thiamine action in rats nearly equal to that of thiamine-HCl. After intravenous injection of TMPDS in a dog, the levels of total thiamine and thiamine diphosphate in blood were much higher than after administration of thiamine-HCl, retaining the level for a longer period.On the other hand, TMPDS trended to retard the urinary excretion and it showed beneficial effects on analgesic action and prevention of fatigue in swimming of mice.As for the general pharmacological action of TMPDS, it showed qualitatively similar behaviors against respiro-circulatory systems to those of thiamine-HCl. The former lowered the blood pressure more slowly than the latter in rabbits. Administration of TMPDS, 20mg per kg, brought about the tension and acceleration of the movement of the intestine in rabbits in situ similarly to thiamine-HCl. In any case, if the pharmacological action of TMPDS is assumed to be a side effect to vitamin action, it is considered to have only a veryr slightly one.Acute toxicity in mice was much slighter than that of thiamine-HCl in mice. The compound was found much more resistant to thiaminase I and II than thiamine-HCl.