Abstract
Siever, Larry J., Thomas W. Uhde, Thomas R. Insel, Walter H. Kaye, David C. Jimerson, C. Raymond Lake, Marian Kafka, Steven Targum, and Dennis L. Murphy: Biologic alterations in the primary affective disorders and other tricyclic-responsive disorders. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1985, 9 (1): 15–24. 1. 1. Noradrenergic function was studied in patients with primary affective disorder and other tricyclic-responsive disorders including obsessive-compulsive disorder, anorexia nervosa and panic attack/agoraphobia in medication-free states. 2. 2. Pre-synaptic noradrenergic activity was assessed by assaying plasma concentrations of norepinephrine (NE) and its metabolite 3-methoxy,4-hydroxyphenylglycol (MHPG). 3. 3. Noradrenergic receptor responsiveness was evaluated by measuring plasma growth hormone (GH), MHPG, and NE responses to clonidine. 4. 4. Binding of tritiated dihydroergocriptine ( 3H-DHE) and biochemical responsiveness of α 2-adrenergic receptors were measured in platelet preparations. 5. 5. These studies suggest that noradrenergic activity may be altered in several tricyclic-responsive disorders and are consistent with the possibility that tricyclic antidepressants may serve to stabilize a dysregulated noradrenergic system in patients from several diagnostic categories.
Published Version
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