Abstract
SummaryThe anti-inflammatory, liver glycogenic, and sodium retaining activities of a series of 6α-fluoro and 16α-methyl steroids and their parent compounds were determined. The 6α-fluoro substitution increased liver glycogenic activity in all compounds studied, and anti-inflammatory potency in all but one of compounds. This modification also produced variable effects on sodium retention. The 16α-methyl group did not consistently increase liver glycogenic or anti-inflammatory activities. Sodium retention effect of the corticoids was not increased by 16-methylation if parent compound did not possess mineralo-corticoid activity. In examples where parent steroid was a sodium retainer, addition of 16α-methyl group caused reduction of this activity.
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