Abstract
BackgroundBauhinia racemosa Lam. (BR) has been used widely for the treatment of diabetes since ancient times. Along with its medicinal importance; the tree having great traditional value in India. The protocol was performed using Wistar rats to determine the effect of petroleum ether extract of BR leaves on blood glucose level, adipose tissue and lipid profile. The study was further evaluted to determine insulin level, glucose tolerance, food and water intake of the animals.MethodsWistar rats of both sexes were selected for the study. Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) 45 mg/kg. Animals were divided into five groups namely control group, diabetic group, reference group (glibenclamide) and two test groups BR-1 (250 mg/kg extract) and BR-2 (500 mg/kg) each group containing 6 animals. Daily dosing was performed for 28 days and feed and water consumption was observed regularly at the end of the study.ResultsThe main finding of the study for the test extract was that the petroleum ether extract of BR leaves prevented a rise in blood glucose level in STZ induced diabetic animal. Furthermore, extract showed significant antiadipogenic and antihyperlipidemic effect. It improved lipid profile by decreasing the levels of serum triglycerides, total cholesterol, low-density lipoprotein (LDL) and increasing high-density lipoprotein (HDL) cholesterol. Extract exhibited the concentration-dependent inhibitory effect with an IC50 value of 660.26 μg/ml.ConclusionsIt can be concluded from the study that BR extract posses signigicant antidiabetic activity by reducing blood glucose level of diabetic rats. It also normalized adipose tissues and lipid level. Due to its potential, it may be an effective drug for treatment of diabetes and related complications like obesity and dyslipidemia.
Highlights
Bauhinia racemosa Lam. (BR) has been used widely for the treatment of diabetes since ancient times
Diabetes mellitus is a metabolic disorder characterized by abnormal carbohydrate, protein and fat metabolism due to deficient insulin action on target tissues which results in hyperglycemia [1]
Phytochemical screening The petroleum ether extract of BR leaves was subjected to different chemical tests separately for identification of various active constituents employing standard protocols recommended by WHO [17]
Summary
Bauhinia racemosa Lam. (BR) has been used widely for the treatment of diabetes since ancient times. (BR) has been used widely for the treatment of diabetes since ancient times. Along with its medicinal importance; the tree having great traditional value in India. The protocol was performed using Wistar rats to determine the effect of petroleum ether extract of BR leaves on blood glucose level, adipose tissue and lipid profile. The study was further evaluted to determine insulin level, glucose tolerance, food and water intake of the animals. Diabetes mellitus is a metabolic disorder characterized by abnormal carbohydrate, protein and fat metabolism due to deficient insulin action on target tissues which results in hyperglycemia [1]. Poor and harsh climate is favorable for its growth of rare medicinal tree. The tree is widely distributed throughout India, Srilanka, Ceylon, China and Timor [7].
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