Abstract
The main aim of this study is to determine the changes occurred in the antioxidant capacity and UV-protection capacity of rutin with a different redox-potential metal cation. The complexes were characterized by UV-Visible and IR spectroscopy. Rutin belongs to the flavonols and it is a glycoside form of quercetin. Chelate formation is a result of interaction of rutin with metal ions. The chelation of metals can be crucial in the prevention of radical generation, which damages target biomolecules. The interactions between flavonoids and transition metal ions to form complexes that prevent the participation of metal ions in free radical generating processes, thus exhibit an anti-oxidant behavior, metal-flavonoid complexes various biological and pharmacological activities. The coordination of Rutin (Rut) with Rut-Zr, Rut-Mo, Rut-Zn, Rut-Cu, Rut-Ni, Rut-Fe, Cit-Zn, Cit-Mo, Cit-Zr, Cit-Cu, Cit-Fe, and Cit-Ni may simulate the catalyzed centre of the hyperoxide dismutase in the metal coordinate structure, thus displayed the DPPH, hydroxyl radical scavenging activity, metal chelating, and nitric oxide (NO) and superoxide dismutase (SOD) radical scavenging. Therefore, the metal flavonoid complexes are very helpful in discovery and development of new drugs.
Highlights
S Metabolites better than the synthetic ones due their toxicity effects
The results demonstrate that flavonoid-metal complexes possess effective free radical scavenger ability and have potent therapeutic benefits for the treatment of oxidative stress-related diseases and dysfunction
The in vitro antioxidant activity of citrus peels was evaluated by DPPH radical scavenging method; reducing power assay and metal chelating activity compared to the standard viz., Gallic acid, ethylene-diamine-tetraacetate (EDTA), butylated hydroxyl toluene (BHT), catechin, ascorbic acid and citric acid
Summary
S Metabolites better than the synthetic ones due their toxicity effects. In the structure of several flavonoids (Fig1.0) are three potential coordination sites: a) 5-hydroxy and 4-carbonyl group, b) 3-hydroxy and. Effect of serum albumin on stability of flavonoid-metal complexes was studied and complex of rutin with iron (II) was found to be the most stable. The ability of flavonoid metal complexes to catalyze homolytic cleavage of hydrogen peroxide was studied and rutin iron (II) complex was found to be relatively poor Fenton catalyst. The potential therapeutic benefits of this new antioxidant agent were studied using experimental model of pathological states associated with oxidative stress in vivo. It was found that pretreatment with rutin- iron complex protected against thio-acetamide induced hepato-toxicity as observed by a significant reduction in the elevated levels of serum enzymes and partial normalization of GSH/GSSG ratio, glutathione peroxidase II and glutathione reductase activity in mice liver. The results demonstrate that flavonoid-metal complexes possess effective free radical scavenger ability and have potent therapeutic benefits for the treatment of oxidative stress-related diseases and dysfunction. The antioxidant activity of flavonoids may involve their ability to form complex body iron in non-redox-active (Baccan et al (2012)
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