Abstract

The crude extracts and isolated compounds of Artocarpus lanceifolius and Artocarpus maingayi were examined for their antimirobial and antioxidant activities. Most of the compounds and crude extracts showed significant activities against the Gram-positive bacteria, i.e Bacillus subtilis and Staphylococcus aureus and Gram-negative bacteria, i.e Escherichia coli and Pseudomonas aeruginosa. These crude extracts and isolated compounds inhibited the growth of almost all tested microorganisms with inhibition zone diameter between 8-15 mm. 2’, 4’, 5’, 5-tetrahydroxy-7, 8-(2,2dimethylchromeno)flavone showed the most significant antimicrobial activity compared to other isolated compounds and crude extracts followed by cycloartobiloxanthone and acetone crude extract from the stem bark of Artocarpus lanceifolius with the MIC values between 31.3 μg/mL and 125 μg/mL. While the antioxidant activity against crude extracts and pure compounds from both species showed potential free radical scavenging action against DPPH. Artonin E possessed the highest ability as free radical scavenger with the highest SC50 value at 46.9 μg/mL. The ethyl acetate of crude extract from stem bark Artocarpus maingayi showed significant scavenging activity against DPPH with IC50 60.1 μg/mL.

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