Biological Activities and Chemical Composition of Santolina africana Jord. et Fourr. Aerial Part Essential Oil from Algeria: Occurrence of Polyacetylene Derivatives.

Charaf Eddine Watheq Malti,Jacques Maury,Jacques Maury,Clémentine Baccati,Clémentine Baccati,Fewzia Atik-Bekkara,Félix Tomi,Félix Tomi,Magali Mariani,Magali Mariani,Faiçal Hassani,Brahim Babali,Mathieu Paoli,Mathieu Paoli,Chahrazed Bekhechi

doi:10.3390/molecules24010204

Abstract

The chemical composition of 18 oil samples of Santolina africana isolated from aerial parts at full flowering, collected in three locations in eastern Algeria was determined by GC(RI), GC/MS and 13C-NMR analysis. The major components were: germacrene D, myrcene, spathulenol, α-bisabolol, β-pinene, 1,8-cineole, cis-chrysanthenol, capillene, santolina alcohol, camphor, terpinen-4-ol and lyratol. The chemical composition appeared homogeneous and characterized by the occurrence of four derivatives which exhibited a conjugated alkene dialkyne moiety. They were identified for the first time in an essential oil from S. africana. The collective oil sample exhibited moderate antimicrobial and antioxidant activities whereas the anti-inflammatory activity presented a real potential. IC50 value of Santolina africana essential oil (0.065 ± 0.004 mg/mL) is 5-fold higher than IC50 value of NDGA used as positive control.

Highlights

The Santolina genus belongs to the Asteraceae family and is represented by more than 10 species widely distributed in Mediterranean area [1]
The composition of S. africana aerial part oils isolated from plants growing wild in eastern
Algeria (Batna) was different from those reported for oils from Morocco [4,5], Tunisia [9] and Algeria (Constantine) [7,18], but it should be pointed that a similar composition has been reported for flowerhead oil of S. chamaecyparissus from Tunisia, which contained 1,8-cineole, β-eudesmol

Summary

Introduction

The Santolina genus belongs to the Asteraceae family and is represented by more than 10 species widely distributed in Mediterranean area [1]. W. (South of France and North of Spain), S. pectinata Lag. (= S. rosmarinifolia L.) (Iberian Peninsula) and S. chamaecyparissus L. are the most widely spread species around the world. Et Maire and S. chamaecyparissus L. var. It is an endemic species to the North Africa (Morocco, Algeria and Tunisia) [2,3]. That grows naturally in forests and steppe pastures. This species is a bushy, green or ashy sub-shrub. The stems are woody, with floriferous branches erect in tuft, bare and thickened at the apex. The flowerheads are discoidal, yellow, homogamous [2]

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