BIOLOGICAL ACTIVE COMPOUNDS SALSOLA TRAGUS L. (CHENOPODIACEAE) AS A PROMISING PHARMACOLOGICAL OBJECT OF UKRAINE

Abstract

Introduction. Evaluation of high-quality composition and content of biologically active compounds of Salsola tragus grass as promising raw materials for the pharmaceutical industry. Aim. To determine the chemical composition of the above-ground part of the Black Sea species of S. tragus for the purpose of its use in medicine. Materials and Methods. The study of biologically active compounds S. tragus were conducted in the summer of 2020. Grass samples were collected along the field road near the coast of the Tiligul estuary. The above-ground biomass of this species was analysed. The total content of lipids and their fatty acid composition, the content of carbohydrates, phenolic compounds and their derivatives were studied by generally accepted methods. The acidity titre was determined using a solution of oxalic acid. Main results. 11 compounds of phenolic nature, among which 5 phenoloxides (ferulic, cinnamic, caffeic, gallic and chicoric), 1 coumarin (esculetin) and 5 flavonoids (quercetin, rutin, luteolin-7-glucoside, hyperoside, hesperedin) were identified and quantitatively determined. Ferulic and gallic acid prevail among phenolic acids. Among the flavonoids luteoline-7-glucoside and hesperedin prevailed. Grass S. tragus was quite rich on lipid components. In their composition, 8 fatty acids were found. The content was dominated by unsaturated fatty acids with the domination of linoleic and oleic acids – 27.67 and 19.27 % respectively. The largest content among the investigated biologically active compounds of S. tragus belongs to the total carbohydrates (8.31%). The titre of raw material was 1.8%. Conclusions. On the basis of a comprehensive study of biologically active compounds of grass S. Tragus it is possible to conclude that it can be used as a source of phenolic compounds, in particular flavonoids having a significant antioxidant, anti-inflammatory, antitumor, antimony activity, and oleic acid, which positively affects the exchange of cholesterol and essential fatty acids (ω-3 and ω-6) for the production of new phytomedications.