Abstract
The problem of biologic false positive reactions in serologic tests for syphilis has been considered in relation to certain basic clinical and immunologic aspects. These include the clinical definition and recognition of a biologic false positive reaction, the requirements of a valid serologic method of differentiation and the immunologic nature of the antibodies and antigens. Recent developments in the serologic diagnosis of syphilis are reviewed and critically considered, with special reference to the introduction of cardiolipin and the euglobulin-inhibition test. The present status of the problem of biologic false positive reactions has been evaluated, with consideration of the possible clinical and immunologic limitations to complete resolution of the problem.
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