Abstract
This article reviews the bioinspired design and characterization techniques of the different types of micro/nanomotors and their biomedical applications in cancer diagnosis and treatment.
Highlights
According to the recent GLOBOCAN 2020 database, the estimated global cancer burden shows 19.3 million newly affected people and 10.0 million deaths in 2020.1 The rate of recovery from cancer tends to be very low, most likely due to late-stage diagnosis and limited access to timely and standard treatment
Yu et al have developed an autonomous micromotor based on gold-nanoparticlemodified self-propelled polyaniline/Pt functionalized with a specific capture antibody and glycidyl methacrylate (GMA) microspheres on the surface for in situ detection of cancer biomarkers, carcinoembryonic antigen (CEA) (Fig. 6c).[101]
The developed micro/nanomotors are being known as the “new generation multitasking asset”, which can perform various tasks, such as diagnosis, imaging and targeted drug delivery in cancer therapeutics
Summary
According to the recent GLOBOCAN 2020 database, the estimated global cancer burden shows 19.3 million newly affected people and 10.0 million deaths in 2020.1 The rate of recovery from cancer tends to be very low, most likely due to late-stage diagnosis and limited access to timely and standard treatment. The field of nanomedicine has received tremendous attention towards improved disease diagnostics, the delivery of therapeutic and imaging payloads, and tissue engineering, among others.[15,16,17,18,19,20] Considerable efforts have been devoted towards the design of different strategies and nanoplatforms for targeted delivery in vivo and probing the cellular function.[21] In nature, the highly efficient biological motors perform complicated tasks by converting fuel, typically adenosine triphosphate (ATP), into mechanical motion These natural motors are involved in almost every aspect of cell life including division, growth and migration. These include an illustration of the strategies for detecting of cancer biomarkers and the cancer cells using nano/micromotors, as well as the recent advances for the future therapy of cancer through direct cell capture and removal; killing by direct contact or specific drug delivery to the affected site
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