Abstract
The biological features of the valvular heart disease with atrial fibrillation (AF-VHD) remain unknown when involving long non-coding RNAs (lncRNAs). This study performed system analysis on lncRNA and messenger RNA (mRNA) expression profiles constructed by using bioinformatics methods and tools for biological features of AF-VHD. Fold change and t-test were used to identify differentially expressed (DE) lncRNAs and mRNAs. The enrichment analysis of DE mRNAs was performed. The subgroups formed by lncRNAs and nearby mRNAs were screened, and a transcriptional regulation network among lncRNAs, mRNAs, and transcription factors (TFs) was constructed. The interactions between mRNAs related to lncRNAs and drugs were predicted. The 620 AF-VHD-related DE lncRNAs and 452 DE mRNAs were identified. The 3 lncRNA subgroups were screened. The 665 regulations mediated by lncRNAs and TFs were identified. The 9 mRNAs related to lncRNAs had 1 or more potential drug interactions, totaling 37 drugs. Of these, 9 drugs targeting 3 genes are already known to be able to control or trigger atrial fibrillation (AF) or other cardiac arrhythmias. The found biological features of AF-VHD provide foundations for further biological experiments to better understand the roles of lncRNAs in development from the valvular heart disease (VHD) to AF-VHD.
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