Abstract
Colorectal cancer has been ranked as the second cause of death in the United States of America. Bioinformatic analysis of gene expression datasets including GSE10402 and GSE110224 were complemented to identify differentially expressed genes between recurrent and colorectal cancer patients. A total of 73 overlapped differentially expressed genes were screened out that were specifically changed in compare with recurrent colorectal cancer tissues. Most of the pathways were enriched in genes contributing in signaling, nuclear transcription factor complex and ubiquitin protein ligase activity. Protein-protein construction was complemented and additionally 10 hub-genes were selected in protein-protein interaction construction. As a conclusion, our results may possibly help to divulge the manner which colorectal cancer tissues may be changed into the recurrent cancer cells and other researchers can investigate more target genes in clinical treatments.
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