Abstract
We aim to identify the common genes, biological pathways, and treatment targets for primary Sjögren's syndrome patients with varying degrees of fatigue features. We select datasets about transcriptomic analyses of primary Sjögren's syndrome (pSS) patients with different degrees of fatigue features and normal controls in peripheral blood. We identify common differentially expressed genes (DEGs) to find shared pathways and treatment targets for pSS patients with fatigue and design a protein-protein interaction (PPI) network by some practical bioinformatic tools. And hub genes are detected based on the PPI network. We perform biological pathway analysis of common genes by Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. Lastly, potential treatment targets for pSS patients with fatigue are found by the Enrichr platform. We discovered that 27 DEGs are identified in pSS patients with fatigue features and the severe fatigued pSS-specific gene is RTP4. DEGs are mainly localized in the mitochondria, endosomes, endoplasmic reticulum, and cytoplasm and are involved in the biological process by which interferon acts on cells and cells defend themselves against viruses. Molecular functions mainly involve the process of RNA synthesis. The DEGs of pSS are involved in the signaling pathways of viruses such as hepatitis C, influenza A, measles, and EBV. Acetohexamide PC3 UP, suloctidil HL60 UP, prenylamine HL60 UP, and chlorophyllin CTD 00000324 are the four most polygenic drug molecules. PSS patients with fatigue features have specific gene regulation, and chlorophyllin may alleviate fatigue symptoms in pSS patients.
Highlights
Primary Sjögren’s syndrome is an all-body autoimmune disease that mainly affects middle-aged women [1]
We use the GSE66795 dataset to identify the differentially expressed genes (DEGs) of Primary Sjögren’s syndrome (pSS) with fatigue. 37, 29, and 33 DEGs are obtained for pSS with mild, moderate, and severe fatigue, respectively
The collected DEGs are further compared by using the online website for gathering common genes in pSS with varying degrees of fatigue
Summary
Primary Sjögren’s syndrome (pSS) is an all-body autoimmune disease that mainly affects middle-aged women [1]. Fatigue is commonly seen in pSS patients as an extraglandular manifestation and closely links with poor life quality [4,5,6]. Fatigue affects approximately 70% of pSS patients [7, 8]. Fatigue and depression are considered manifestations of psychological disorders and interact with physical pain and discomfort, which creates a vicious cycle. Fatigue in pSS is induced and regulated by genetic and molecular mechanisms, with the innate immune system playing an important role in the production of fatigue [9,10,11]. PSS always comes with fatigue, not all patients exhibit fatigue, which provides a good model for exploring the underlying biological mechanisms
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
