Abstract
Seven compounds were extracted and purified from the roots of Michelia compressa var. lanyuensis. These compounds are liriodenine, (−)-N-acetylanonaine, pressalanine A, p-dihydroxybenzaldehyde, 3,4-dihydroxybenzoic acid, (−)-bornesitol and β-sitostenone. These compounds were screened for anti-proliferation and anti-tyrosinase activities in B16F10 cells. Liriodenine, pressalanine A, (−)-bornesitol and β-sitostenone displayed cytotoxicity at high concentration (100 μM), but liriodenine (5 μM), (−)-N-acetylanonaine (10 μM), and β-sitostenone (5 μM) inhibit tyrosinase activity and reduce the melanin content in B16F10 cells without cytotoxicity, suggesting that liriodenine and β-sitostenone could be safe and potentially used in cosmetic skin whitening.
Highlights
The genius Michelia has 30 species and is distributed in Asia
The cells were treated with compounds at different concentrations (1, 10, and 100 μM) as demonstrated in Liriodenine (1), pressalanine A (3), (−)-bornesitol (6) and β-sitostenone (7) produced cytotoxicity at high concentration (100 μM)
We discovered that the decrease in melanin contents matched the tyrosinase activity inhibition with the same tendencies
Summary
Many bioactive compounds have been isolated from the Magnoliaceae, including alkaloids, aporphines, linalool and so on [1,2]. Non-melanoma skin cancer includes squamous cell carcinoma [12]. As part of our ongoing research program to isolate and identify bioactive compounds from natural sources, in this work the bioactive constituents of the roots of Michelia compressa var. Were further investigated by assaying their anticancer effects and tyrosinase and cellular proliferation inhibition, We isolated seven bioactive compounds, namely liriodenine (1), (−)-N-acetylanonaine (2), pressalanine A (3), p-dihydroxybenzaldehyde (4), 3,4-dihydroxybenzoic acid (5), (−)-bornesitol (6) and β-sitostenone (7). Pressalanine A (3), 3,4-dihydroxybenzoic acid (5) and (−)-bornesitol (6) were isolated for the first time from this plant
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