Abstract
Acinetobacter baumannii is a member of the ESKAPE pathogens, notorious for causing multidrug resistant nosocomial infections worldwide. Biofilm has an important role in its persistence and spread in hospital environment, as well as its multidrug resistance potential. The present study was aimed at finding out whether the strength of Biofilm formation varies with infection of different organs / system. A total of 136 isolates of Acinetobacter baumannii were taken from a variety of samples. Strength of Biofilm formation, determined by Tissue culture plate method, was graded according to OD value in ELISA reader as nil, moderate and strong. It was seen that association between variations in biofilm forming capacity depending on different sites of infection was statistically significant. We suggest biofilm typing by this method for this pathogen, as a potentially feasible alternative in countries with cost restrained healthcare set ups. Moreover, biofilm typing report would be more meaningful to the clinicians as well.
Highlights
In the bygone days, there was a group infamous for its criminal activity, especially murders, dreaded by all
The ESKAPE pathogens comprise of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp. [1]
It is well accepted that Acinetobacter baumannii shows the presence of dormant cell, a feature rarely noted in other gram negative bacteria
Summary
There was a group infamous for its criminal activity, especially murders, dreaded by all. Acinetobacter baumannii was earlier considered to be only an opportunistic pathogen, causing ventilator associated pneumonia the patients admitted in the intensive care units It has increased its virulence potential over the years, and is being increasingly the isolated from infections involving each and every organ. The clear message which came out from the symposium was that carbapenem resistant strains of Acinetobacter baumannii are continuously spreading throughout the world. It is well accepted that Acinetobacter baumannii shows the presence of dormant cell, a feature rarely noted in other gram negative bacteria This accounts for it’s environmental persistence – an ability to survive for a long time on abiotic surfaces under dry condition. Substratum or interface or to each other, are embedded in a matrix of extracellular polymeric substances that they have produced , and exhibit an altered phenotype with respect to growth rate and gene transcription.[9]
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