Abstract
Implantable nerve electrodes, as a bridge between the brain and external devices, have been widely used in areas such as brain function exploration, neurological disease treatment and human–computer interaction. However, the mechanical properties mismatch between the electrode material and the brain tissue seriously affects the stability of electrode signal acquisition and the effectiveness of long-term service in vivo. In this study, a modified neuroelectrode was developed with conductive biomaterials. The electrode has good biocompatibility and a gradient microstructure suitable for cell growth. Compared with metal electrodes, bioelectrodes not only greatly reduced the elastic modulus (<10 kpa) but also increased the conductivity of the electrode by 200 times. Through acute electrophysiological analysis and a 12-week chronic in vivo experiment, the bioelectrode clearly recorded the rat’s brain electrical signals, effectively avoided the generation of glial scars and induced neurons to move closer to the electrode. The new conductive biomaterial electrodes developed in this research make long-term implantation of cortical nerve electrodes possible.
Highlights
In recent years, cortical nerve electrodes, as a tool for studying neuroscience and understanding brain function, have received more and more attention due to their wide applications in biomedicine/rehabilitation [1,2,3,4,5,6,7]
Implantable nerve electrodes can mainly be divided into the following categories: the first one is a metal micro-wire electrode, which is made of gold, platinum, iridium, tungsten and other metals or metal alloys, and its diameter is generally less than 100 μm
The first to minimize the gap of gap mod-of modulus between the electrode the brain tissue premise ensuringthe the ulus between the electrode and and the brain tissue on on thethe premise ofofensuring mechanical stability of the electrode itself to reduce the mechanical damage to the brain mechanical stability of the electrode itself to reduce the mechanical damage to the brain tissuecaused causedby bythe thecontact contactstress stressand andelectrode electrodemicro-movement
Summary
Cortical nerve electrodes, as a tool for studying neuroscience and understanding brain function, have received more and more attention due to their wide applications in biomedicine/rehabilitation (such as regulating the growth of neurons, using as the brain–computer interface, repairing the nervous system, etc.) [1,2,3,4,5,6,7]. The glial layer insulates the implant from adjacent nerve cells to increase the impedance of the electrode This interruption may lead to the degradation of the quality of the signal and limit the function of the electrode. Intoaddition, by coating theimpedance recording electrode conductive polymers, it is possible reduce the electrode for betterwith bonding with materials such as carbon nanotubes and conductive polymers, it is possible to reduce nerve tissue. These interventions enhance the adhesion of nerve cells to the electrode to the electrode better tissue.
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