BioEssays 5/2011

Abstract

BioEssaysVolume 33, Issue 5 Cover PictureFree Access BioEssays 5/2011 First published: 18 April 2011 https://doi.org/10.1002/bies.201190019AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Cover Photograph: Counterpoints in cancer. The somatic mutation theory (SMT, depicted on the right hand side) has long been the accepted model of carcinogenesis. In this model a cell gradually accumulates mutations in genes critical for cell cycle control and apoptosis, for example, which ultimately turn the cell cancerous. This theory is challenged by an alternative model: the tissue organisation fi eld theory (TOFT, represented on the left hand side) posits that cancer is, instead, a tissue-based disease. This issue of BioEssays features these two radically different stances in a point ↔ counterpoint, attacking and defending the SMT (see pages 332–343). Volume33, Issue5May 2011 RelatedInformation