Cover Picture (Angew. Chem. Int. Ed. Engl. 4/1994)

Abstract

Angewandte Chemie International Edition in EnglishVolume 33, Issue 4 Cover PictureFree Access Cover Picture (Angew. Chem. Int. Ed. Engl. 4/1994) First published: March 3, 1994 https://doi.org/10.1002/anie.199403651Citations: 2AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract The cover picture shows a balance with 1.5010 g of the enantiomerically pure, chiral ketone whose formula is given on the right-hand side of the picture. This compound was synthesized on a preparative scale by the antibody-catalyzed enantioselective hydrolysis of the enol ether shown on the left-hand side. The monoclonal antibody was raised against a hapten (general structure in the box) which is an analogue of the transition state depicted at the top. Thus, catalytic antibodies (see for example the highlight by C. Leumann last year: Angew. Chem. 1993, 105, 1352; Angew. Chem. Int. Ed. Engl. 1993, 32, 1291) can be considered as practical tools for preparative chemistry. J.-L. Reymond, J.-L. Reber, and R. A. Lerner give details on upscaling on pp. 475–477. Citing Literature Volume33, Issue4March 3, 1994 RelatedInformation