Abstract
Background Currently used methods for detecting and monitoring cancer cachexia (CC) are not sensitive enough. In this field, there is a need to implement new instruments into clinical practice. Objective Determining the usefulness of bioelectrical impedance analysis (BIA) for detecting and monitoring CC in patients with colorectal cancer (CRC). Methods 158 people were invited to the study (70 from CRC and 88 controls). Their body composition was determined using BIA, and their nutritional status was determined according to NRS 2002, SGA, and BMI criteria. For statistical data analysis, Student's t-test, Mann–Whitney U test, and AUC ROC were used. Results Men with CRC stage I had higher values of FMI, SMMI, and ECW/TBW (p < 0.05) than in stages II–IV, and women with CRC stage I had higher values of FMI, FFMI, and FM/FFM than in the group of stages II–IV (p < 0.05). The ability of FFMI to detect malnutrition relative to SGA was low (sensitivity: women 40%, men 40% and specificity: women 74%, men 70%). Conclusions SGA and NRS 2002 scales are dynamic and consider changes in nutritional status over time, while BIA is static and does not consider these changes. Therefore, BIA is not a good tool for screening nutritional status. BIA successfully identifies differences in body composition depending on cancer stage and advancement of CC. Therefore, after the diagnosis CRC, just to monitor the disease advancement and state of CC, it is worth comparing the results of periodically repeated BIA.
Highlights
Used methods for detecting and monitoring cancer cachexia (CC) are not sensitive enough
158 people were invited to the study (70 from colorectal cancer (CRC) and 88 controls). eir body composition was determined using bioelectrical impedance analysis (BIA), and their nutritional status was determined according to NRS 2002, Subjective Global Assessment (SGA), and BMI criteria
AUC ROC and Youden’s index (I-Youden) were used to determine the cutoff points for BIA parameters distinguishing wellnourished from undernourished subjects, and SGA was taken as a reference
Summary
Used methods for detecting and monitoring cancer cachexia (CC) are not sensitive enough. In this field, there is a need to implement new instruments into clinical practice. Determining the usefulness of bioelectrical impedance analysis (BIA) for detecting and monitoring CC in patients with colorectal cancer (CRC). Eir body composition was determined using BIA, and their nutritional status was determined according to NRS 2002, SGA, and BMI criteria. SGA and NRS 2002 scales are dynamic and consider changes in nutritional status over time, while BIA is static and does not consider these changes. Erefore, after the diagnosis CRC, just to monitor the disease advancement and state of CC, it is worth comparing the results of periodically repeated BIA BIA successfully identifies differences in body composition depending on cancer stage and advancement of CC. erefore, after the diagnosis CRC, just to monitor the disease advancement and state of CC, it is worth comparing the results of periodically repeated BIA
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