Abstract
In this article, Sodium alginate and Lignosulphonic acid blends were prepared in different weight ratios by solution casting method. Swelling experiments were conducted for Sodium alginate and its blends by adding calcium chloride for various intervals in a pH 7.4 medium. The strength of the films increases after their treatment with CaCl2 at higher intervals forming an alginate network. The SA/LS blend (80/20) is subjected for sorption studies at variable pH 1.2 & 7.4, in order to test the suitability of the blends for controlled drug delivery. Further, experiments were conducted for de-crosslinking using 0.1M HCl. The solvent uptake for the blends decreased with increasing LS content in the blends. Blends were investigated by X-ray diffraction and Fourier Transform Infra-Red spectroscopy in order to study the crystallinity and molecular interactions. XRD confirms the reduction in cluster space in blends leading to lower uptake of solvent.
Highlights
Experimental ÉSodium alginate (SA) blends are the biodegradable polymers that are soluble in water and various other aqueous solvents
The transport behavior of SA, SA/Lignosulphonic acid (LS) blends has been examined for water uptake in phosphate buffer of pH (7.4) as probe molecules at the room temperature
The strength of the blends and pure SA can be achieved by using calcium chloride as crosslinking agent for selective permeation
Summary
Sodium alginate (SA) blends are the biodegradable polymers that are soluble in water and various other aqueous solvents. C application in various biomedical fields has been a major area of Sodium alginate (MW=300000 gm/mol) and lignosulphonic study over the last half century. The sodium alginate hydrogels acid (MW = 50000 gm/mol) were used as obtained from Sigma are largely used due to their high biocompatibility[1]. The application of alginate hydrogels as scaffolding materials has attracted much attention in the areas of tissue engineering[2].
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