Abstract
Poly(D,L-lactic acids) (PLA) with number-average molecular weights (Mn) of 1400, 2000 and 4400 were synthesized by polycondensation in the presence of water, to investigate the degree of in-vivo degradation and the degradation patterns. The degree of degradation of PLA implanted subcutaneously in the back of rats was found to be approximately 100, 42, and 5%, respectively, at the third week from the start of the implantation, during which the degradation pattern was changed from parabolic-type to S-type, as the molecular weight was increased. A synthetic analogue of eel calcitonin, [Asu1,7]-ECT, was incorporated into a fine cylinder of PLA. The initial burst of drug released in-vivo from the cylindrical PLA formulation could be retarded by adjusting the molecular weight of the polymers.
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