Biocompatible polymer functionalized magnetic nanoparticles for antimicrobial and anticancer activities

Abstract

Polymer functionalized transition metal oxide (TMO)-NPs are the future of cancer therapy and antimicrobial activities. Present study was related to synthesis of pure, chitosan (CH) and polyethylene glycol (PEG) coated Fe3O4-NPs via co-precipitation method. The XRD analysis represents the cubic lattice structure and crystallite size varies from 11 to 21 nm. The SEM micrograph shows that the irregular and dendrimer like surface morphology by using the (PEG and CH) coating agents. To investigate the different functional groups carboxyl, hydroxyl, amino groups, FeO and CH2 in pure and coated spectrum of Fe3O4-NPs by using FTIR. The VSM analysis shows that the coercivity increase Hci (m = 0) 11.281 Oe, 45.135 Oe, 51.127 Oe and magnetization decrease (Ms) 7.5001E-3 emu, 5.2432E-3 emu and 4.7801E-3 of polymer coated Fe3O4-NPs. In-vitro bioassay, the antimicrobial activities were observed against Escherichia coli (E.coli), Bacillus cereus (B.cereus) and Fusarium avenaceum (F.avenaceum), these results shows that the inhibition zone increase from 9 to 14 mm. The biotoxicity was tested against hepatocellular carcinoma (HepG2) cell lines via MTT assay. The overall assessment indicated that the PEG coated Fe3O4-NPs give the significant results against antimicrobial and anticancer activities. In future, surface functionalized magnetic nanomaterials will be playing the central role for hyperthermia therapy and wound healing purpose.