Biocompatibility of intraocular lens power adjustment using a femtosecond laser in a rabbit model

Abstract

To evaluate the biocompatibility (uveal and capsular) of intraocular lens (IOL) power adjustment by a femtosecond laser obtained through increased hydrophilicity of targeted areas within the optic, creating the ability to build a refractive-index shaping lens within an existing IOL. John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Experimental study. Six rabbits had phacoemulsification with bilateral implantation of a commercially available hydrophobic acrylic IOL. The postoperative power adjustment was performed 2weeks after implantation in 1 eye of each rabbit. The animalswere followed clinically for an additional 2weeks and then killedhumanely. Their globes were enucleated and bisected coronally just anterior to the equator for gross examination from the Miyake-Apple view to assess capsular bagopacification. After IOL explantation for power measurements, the globes were sectioned and processed for standard histopathology. Slitlamp examinations performed after the laser treatments showed the formation of small gas bubbles behind the lenses that disappeared within a few hours. No postoperative inflammation or toxicity was observed in the treated eyes, and postoperative outcomes and histopathological examination results were similar to those in untreated eyes. The power measurements showed that the change in power obtained was consistent and within ±0.1 diopter of the target. Consistent and precise power changes can be induced in the optic of commercially available IOLs invivo by using a femtosecond laser to create a refractive-index shaping lens. The laser treatment of the IOLs was biocompatible.