Abstract
This study was performed to appraise the biocompatibility of polyhedral oligomeric silsesquioxane (POSS)-grafted polyurethane (PU) nanocomposites as potential materials for muscle tissue renewal. POSS nanoparticles demonstrate effectual nucleation and cause noteworthy enhancement in mechanical and thermal steadiness as well as biocompatibility of resultant composites. Electrospun, well-aligned, POSS-grafted PU nanofibers were prepared. Physicochemical investigation was conducted using several experimental techniques, including scanning electron microscopy, energy dispersive X-ray spectroscopy, electron probe microanalysis, Fourier transform infrared spectroscopy, and X-ray diffraction pattern. Adding POSS molecules to PU did not influence the processability and morphology of the nanocomposite; however, we observed an obvious mean reduction in fiber diameter, which amplified specific areas of the POSS-grafted PU. Prospective biomedical uses of nanocomposite were also appraised for myoblast cell differentiation in vitro. Little is known about C2C12 cellular responses to PU, and there is no information regarding their interaction with POSS-grafted PU. The antimicrobial potential, anchorage, proliferation, communication, and differentiation of C2C12 on PU and POSS-grafted PU were investigated in this study. In conclusion, preliminary nanocomposites depicted superior cell adhesion due to the elevated free energy of POSS molecules and anti-inflammatory potential. These nanofibers were non-hazardous, and, as such, biomimetic scaffolds show high potential for cellular studies and muscle regeneration.
Highlights
Nanoscaffolds with superior biocompatibility as well as proper potency to retain their form can be used for biointegration and will unquestionably provide a priceless substitute to current materials
The presence of dispersed polyhedral oligomeric silsesquioxane (POSS) nanocrystals in hybrid matrices was confirmed by XRD (Figure 2)
Due to the amorphous behavior of PU polymer, no sharp structures were found in the XRD spectrum (Figure 2a) [34]
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Hybrid (organic/inorganic) nanocomposites prepared from polyhedral oligomeric silsesquioxane (POSS) have drawn substantial attention due to numerous beneficial purposes that typically originate from distinctive physical properties of POSS. Tissue engineering is a very promising field that offers surprising ventures in regenerative medicine. This area is focused on the search for substitutes to alleviate pain by reinstating the functions of injured cells and organs [1]. The choice of material for designing scaffold remains a central objective for successful tissue engineering approaches [2]. Composite materials based on organic polymers and inorganic particles are employed for multiple purposes [3]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
