Abstract
Cellular biocircuit design has taken a major step forward. The circuit reuses the cell's own protein-degradation system to synchronize the expression of two synthetic modules throughout an entire bacterial population. See Letter p.387 A major challenge in synthetic biology is that of integrating individual regulatory modules into larger circuits in a noisy and highly interconnected cellular environment. Jeff Hasty and colleagues tackle this problem by recruiting a host-cell protein-degradation system to synchronize genetic circuits and obtain delay times much shorter than those achieved by transcription-based coupling. They then apply this post-translational engineering scheme to synchronize cellular clocks and enable bacterial colonies to respond to independent environmental cues in 'frequency multiplexing'.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call